STEM CELLS MOBILIZED FROM ADIPOSE TISSUE

СТВОЛОВЫЕ КЛЕТКИ МОБИЛИЗОВАННЫЕ ИЗ ЖИРОВОЙ ТКАНИ

Adipose tissue is a more easily accessible biological material compared to bone marrow, the main source of MSCs. MSCs derived from adipose tissue are better suited for use in traumatology and orthopedics, as they differentiate more efficiently into bone tissue cells. In addition, adipose tissue MSCs can stimulate vascular growth through the secretion of vascular endothelial growth factor (VEGF), which makes them effective in diseases such as lower limb ischemia.

                               TYPE 1 DIABETES THERAPY

MSCs isolated from patients with type 1 diabetes recently after diagnosis do not show phenotypic or functional impairment as a result of deleterious inflammatory and metabolic diabetic conditions. This allows the use of MSCs for the treatment of patients with newly diagnosed DM1.

pubmed.ncbi.nlm.nih.gov/26781648/

Stem cell therapy requires a large number of human cells of a particular type. Exposure of near-infrared laser to adult stem cells derived from human body fat causes stem cells to proliferate 54% faster. After that, with the help of a green laser, stem cells are transformed into different types of cells faster and more reliably.

Red (600–700 nm) and near infrared (780–1100 nm) wavelengths promote cell proliferation. Wavelengths of light such as green (495–570 nm) have been found to affect ADMSC differentiation (undifferentiated adipose-derived mesenchymal stem cells).

www.sciencedirect.com/science/article/pii/S0300908421001838

We use therapy with autologous activated MSCs mobilized from adipose tissue in vitro followed by transplantation.

Adult stem cells are found in many tissues and organs, including adipose tissue. They are usually found in a special microenvironment called a «stem cell niche». They remain dormant under normal conditions and are activated when there is a need to repair or preserve damaged tissue. However, when isolated and cultured in vitro or ex vivo, stem cells have a limited ability to proliferate and differentiate. But, low intensity laser therapy (LLLT) stimulates the proliferation of many types of cultured cells, including stem cells.

www.spiedigitallibrary.org/eBooks/TT/Low-Level-Light-Therapy-Photobiomodulation/Chapter8/Low-Level-Laser-Therapy-and-Stem-Cells/10.1117/3.2295638.ch8