Blog

Born in 1890, Hendrikje van Andel-Schipper was once the oldest woman in the world. She was healthy when she died in 2005 and bequeathed her body to science. Scientists studied her blood and other tissues to see how age had affected them. The study showed that our life expectancy:

– is limited by the ability of stem cells to replenish tissues from day to day;

– white blood cells had severely worn out telomeres (17 times shorter).

Aging is directly related to an imbalance in the activity of short and long genes in the transcriptome. The older the animal or person, the more active short genes are in its transcriptome.
The genetic code presented in DNA is translated into RNA inside the cell, turning into a set of instructions. The cell uses this transcript molecule to create its parts and perform various functions. A transcriptome is the totality of all transcripts synthesized by a single cell or group of cells, including mRNA and non-coding RNA.
The content of the transcript changes with age. In a healthy young animal or human, the activity of short and long genes in the transcriptome is balanced, and this balance is carefully controlled and maintained. As an animal or person gets older, short genes begin to dominate this control code. Like the aging process itself, the transition to smaller transcriptomes starts early and proceeds gradually, affecting thousands of individual genes. This suggests that aging is a complex, systemic process that manifests itself immediately and everywhere, literally in all cells of the body. Our interventions allow us to significantly change the ratio/activity of short and long telomeres. www.nature.com/articles/s43587-022-00317-6

We have created an EX VIVO gene therapy technology that reconstructs genomic errors in HSC DNA at any age (normally,
any person accumulates at least 17 mutations per year). Fully restoring clonal hematopoiesis.

Scientists were able to determine the number of stem cells that generate white blood cells by studying the nature of the mutations found in the blood cells. The pattern was so similar in all the cells that it was concluded that they all came from one of two closely related “mother” stem cells. The discovery was that the mutations in the blood cells were harmless – they were all the result of DNA replication errors during life, as the “mother” blood stem cells multiplied to produce clones from which the blood was repeatedly replenished.

genome.cshlp.org/content/24/5/733

To date, there are several main strategies for achieving not only active longevity, but, as shown by recent studies, including our own, biological age reversal. When not only the rate of aging and biological age decreased, but also the so-called “epigenetic rollback” of the biological clock was recorded.

Our team of scientists, in collaboration with numerous scientific centers and clinics, is developing breakthrough biotechnologies in the field of gerontology and geriatrics, oncology, diabetology for the treatment of age-related diseases and special programs for achieving active longevity, as well as real rejuvenation of the body (age reversal).

The possibility of age reversal is shown in scientific works. www.medrxiv.org/content/10.1101/2020.07.07.20148098v1

In addition to the distribution: healthy – having diseases, people are divided into groups, in accordance with the new concept of the characteristics of biological cycles in the body of natural physiological cycles:

Group 1 Up to 34 years;

Group 2 From 34 to 60 years;

Group 3 From 60 to 78 years;

For each of these age groups, there are indications and contraindications for the proposed medical services and interventions.

www.nature.com/articles/s41591-019-0673-2

The program of age correction of homeostasis was named: “Equilibrium” from Latin: “Equilibrium”.

Basic programs:

PROGRAM A (light)

Performed in the Kingdom of Thailand. The protocol includes:

Multifactorial objective determination of bioage (genomic studies, instrumental methods, laboratory) processing of results using neural networks, AI.
Targeting Autologous Modified CAR T Cells to Senescent Cells

A course of intravenous NAD+ transfusions that pursues not only therapy with NAD+ replenishment, but also “dilution” of systemic aging factors;
Long-term course per os of drugs-senalytics, autophagy inducers, telomerase inducers;
Sessions in the pressure chamber for the regulation of telomere length;
Based on the results of the examination, cell therapy aimed at restoring the normal level of NK cells;
Thymus regeneration (growth hormone and pharmaceuticals);
Cosmetology program (contouring), the use of specially developed therapeutic anti-aging agents.
Transplantation of compatible (16Ngs) young microbiota and blood cells;
7-14 days, outpatient / day hospital.

Clinics in Pattaya and Bangkok.

 

PROGRAM B (full)

The program is carried out in the Russian Federation (Moscow), the protocol includes:

The program uses three technologies:
- cell therapy with hematopoietic stem cells;
- gene therapy EX VIVO;
- change in the epigenetic landscape (special procedures based on physical therapies).
Depending on age and condition, the program can be performed in two versions:

hospitalization in a hospital for 14-21 days;
the first stage of hospitalization for 7-14 days, followed by a 2-month break and re-hospitalization for 7 days.
procedures for changing the epigenetic landscape are performed in a day hospital / outpatient setting.
following the results of the program, a large (lifelong) supply of autologous (own) stem cells with a reconstructed genome to maintain polyclonalism is preserved, which are introduced according to a certain algorithm 1-3-5 times a year/years.
The program provides for an in-depth examination of the patient, as well as a special complex genetic study.
As of January 2023, this is the only combined aging therapy program in the world applied to humans.

 

PERMANENTLY OPERATING LONGEVITY CLUB

For those who have completed or are preparing to complete our programs, a permanent club with informal participation has been created. After completing our programs, including seminars, where we explain and teach in detail how and by what means to practically maintain the achieved age reverse, all our club members have 24/7 online support, and also systematically receive the latest information and the opportunity to receive the most modern technologies for achieving healthy longevity.

ENTRY AND PARTICIPATION PROCEDURE:

You submit an application and fill out a simple form, you may be asked to do some tests (at your place of residence) or undergo an examination in our clinics in Moscow or Bangkok (Pattaya);
After receiving the initial data, you will be offered to undergo training for 1 day 4+4 hours in a comfortable environment or 2 days (from 10.00 to 14.00);
You will be able to choose any intervention program after completing which you will be constantly monitored and advised.

Cost of one-time training (seminar) without special programs and monthly support:

1000 Euro, in Moscow (Domodedovo) for two days, we can provide accommodation from luxsure to economy in our rehabilitation center.

900 Euro, in the Kingdom of Thailand (Bangkok, Pattaya), 5* hotel

BRIEF SEMINAR PROGRAM, FOCUS ON PRACTICAL APPLICATION FOR A SPECIFIC PERSON
CAUSES OF AGING AND EXISTING METHODS OF CORRECTION
GENETICS AND EPIGENETICS OF AGING
AGING: DISEASE, PROGRAM, QUASI-PROGRAM?
TELOMERES, CHRONOMERES, HORMONES AT DIFFERENT AGES
MELATONIN, GROWTH HORMONE, NAD+
HAYFLICK LIMIT, CROAT HOURS
BIOAGE (DETERMINATION METHODS), HOW ORGANS AND SYSTEMS AGE
FIBROBLASTS, STEM CELLS, STEM CELL NICHE
GENE THERAPY OF AGING, POLYCLONALITY OF HEMAPOIETIC STEM CELLS
STEM CELLS MOBILIZED FROM ADIPOSE TISSUE
HEMAPOIETIC STEM CELLS
PLASMAPHERESIS, TRANSFUSION OF “YOUNG” PLASMA AND BLOOD ELEMENTS, “DILUTION” OF BLOOD;
CIRCADIAN RHYTHMS, BIORHYTHMS OF RENEWAL OF ORGANS AND TISSUE
CONTROLLED GENE EXPRESSION – BIOLOGICAL, PHARMACOLOGICAL, PHYSICAL
ANTIOXIDANTS, VITAMINS, MICROELEMENTS, NUTRIENTS
VITAMIN D3, VITAMIN C, GROUP B, CALCIUM, MAGNESIUM
GLYCATION END PRODUCTS, DEFINITION, CORRECTION
IHD, atherosclerosis, blood pressure
INTIMMEDIA, ARTERY STIFFNESS, VIRTUAL CORONARY GRAPHY (MSCT)
EXCESSIVE BODY WEIGHT, INTERVAL FASTING
KETOGENIC DIET, REPROGRAMMING WHITE ADIPOSE TISSUE TO BROWN ADIPA TISSUE
MICROBIOME AND MICROBIOTA, 16 NGS, “LEAKY” INTESTINE
HIDDEN FOOD INTOLERANCE AND CORRECT NUTRITION
PRE-PROBIOTICS, FECAL TRANSPLANTATION OF YOUNG DONORS
SPECIAL AND MINIMUM MOTOR ACTIVITY
MEAT AND CANCER, CORRECTION OF HEPATOSIS
AUTOPHAGY, MITOCHONDRIAL HORMESIS
OMEGA-3-6-9;
NEURODEGENERATIVE DISEASES (PARKINSON’S, ALZHEIMER’S)
SPERMIDINE, VITAMIN K, ACC AND GLYCINE
THE MEDITERRANEAN DIET AND THE BLUE ZONES
“MOLECULAR HYDROGEN” (INHALATION, WATER)
FEATURES OF SKIN AGING, ANTI-AGING PROCEDURES, CREAMS, LASERS, ULTRASOUND, SURGICAL TREATMENT
TRADITIONAL HEALTH SYSTEMS (SEA)
SCIENTIFIC VIEW ON SECRET TIBETAN PRACTICES OF “LONG LIFE” – EXERCISES GIVING LIFE WITH SLOW AGING RESTORE NORMAL HAIR COLOR
Gray hair – HOW TO ELIMINATE WITH DIFFERENT APPROACHES
AYURVEDA SYSTEM (RASAYANA) REJUVENATING THERAPY
ASHWADANGHA, TRIPHALA, AYURVEDIC OIL MASSAGE
MEDITATION-TYPES FOR HEALTH, LASER ILLUMINATION OF LONGEVITY POINTS (LOGIC OF TRADITIONAL APPROACHES);
INCREASING TESTOSTERONE LEVELS BY PHYSICAL METHODS (LASERS)
INFUSIONS (DROPPERS) OF LONGEVITY COCKTAILS
AIR QUALITY, WHERE TO GO WALKS?
EVEN THE COLOR OF CLOTHES AND WALLS IN THE HOUSE INFLUENCES LONGEVITY
CAR-T CELL PREPARATIONS FOR REMOVAL OF SENESCENT CELLS
SENOLYTICS AND AUTOPHAGY INDUCTORS
HYPERBARIC OXYGENATION (HYPERBARIC CHAMBER)
HEALTHY ANTI-AGING CHOCOLATE
HEALTHY REJUVENATING SALT
EXOSOMOTHERAPY

PACKAGE PROGRAM FOR NON-CLUB MEMBERS CONDUCTED IN DOMODEDOVO (Moscow Region)

By performing two non-invasive outpatient procedures, a safe, reliable increase and change in the quality of telomeres is achieved, and most importantly, a change in the epigenetic landscape characteristic of centenarians. Over the past 15 years, first on laboratory animals, and then on healthy older people, as well as people with age-related diseases (diabetes, cancer), we have recorded a significant decrease in bioage using Horvath watch models and other methods of objectively assessing bioage 8-12 years. To do this, once a month for 6 months:

1 Session in a pressure chamber 40-60 minutes;

2 Session in the device, which received the working name: “Bioreactor”. This is a physical device with an area of more than 200 square meters that uses special natural frequency ranges up to 300 THz, “selected” from young healthy (pubertal) organisms compatible according to certain parameters. 28 min. Special conditions: to carry out the procedure, it is necessary either to carry out the procedure simultaneously with a young 1st degree relative (absolutely safe for the relative and has no consequences), or a conditional donor is selected based on special tests (Invitro).

Changing the epigenetic landscape allows one to specifically influence groups of genes associated with the aging process and “copy” the epigenetic profile of centenarians and supercentenarians. More details: https://bez-tabletok.ru/bioreactor/

PRICE:

Includes procedures, accommodation, meals (breakfast).

Donor available: 49,000 rub./month;

Donor search required: RUB 69,000/month.

The price is valid for practically healthy people. For patients with one or another pathology, the procedure is different.

TERMS:

There are four cycles that form the basis of methylation:

urea cycle;
ammonia cycle;
folate cycle;
methionine cycle.
The methylation cycle is a common biochemical pathway that governs and promotes a wide range of essential body functions, including:

turning genes on and off (regulation of gene activity);
neutralization of chemicals and toxins coming from outside and formed inside the body;
synthesis of neurotransmitters (dopamine, serotonin, adrenaline);
hormone metabolism (estrogens);
maturation of immune cells (T cells and NK cells);
synthesis of DNA and RNA (thymine is formed from uracil);
energy production (CoQ10, carnitine and ATP);
production of a protective covering for the axons of nervous tissue (myelination process).
Why is the methylation cycle important?
The processes of repair, production of cellular energy, regulation of DNA activity, neutralization of toxic metabolites, etc., help the body respond to environmental stressors, adapt and recover. This is why a decrease in methylation function contributes to the emergence of chronic conditions that are the basis of diseases such as:

cardiovascular diseases;
cancer;
diabetes;
neurological disorders in adults;
autism and other spectrum disorders, mental disorders;
chronic fatigue syndrome;
Alzheimer’s disease;
infertility, miscarriage;
allergies, pathology of the immune system;
aging.
Regulation of the methylation cycle
Methylation is regulated by key enzymes and cofactors, but can also be indirectly influenced by physical methods (lasers, electromagnetic fields).